The management of intraabdominal infections from a global. Guidelines by the surgical infection society and the infectious diseases society of america. Idsa, hivma recommend criteria for easing covid19 control efforts. The surgical infection society is committed to providing leadership in the. These guidelines were developed to inform initial selection of empiric antimicrobial therapy for children at ucsf benioff childrens hospital san francisco and affilitated outpatient sites. The 2002 cutoff was used because relevant literature available through 2002 was used for. Abdominal sepsis represents the hostssystemic inflammatory response to intraabdominal infections.
Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity. Intraabdominal abscess answers are found in the johns hopkins abx guide powered by unbound medicine. Intraabdominal infections iais include many pathological conditions, ranging from uncomplicated appendicitis to faecal peritonitis, presenting a wide variation in the severity of illness for the different forms. The cornerstones of effective treatment of iais are early recognition, adequate source control, and appropriate antimicrobial therapy. The guidelines are intended for treating patients who. Pancreatitis treatment mild to moderate pancreatitis no antibiotics severe acute pancreatitis sap no prophylactic antibiotics no necrosis no antibiotics sterile pancreatic necrosis no antibiotics. Guidelines for the selection of antiinfective agents for. These guidelines, from the infectious diseases society of america idsa, the surgical infection society, the american society for microbiology, and the society of infectious disease pharmacists, contain evidencebased recommendations for selection of antimicrobial therapy for adult patients with complicated intraabdominal infections. Updated guideline on diagnosis and treatment of intra. These guidelines, from the infectious diseases society of america idsa, the surgical infection society, the american society for microbiology, and the society of infectious disease pharmacists, contain evidencebased recommendations for selection of antimicrobialtherapy for adult patients with complicated intraabdominalinfections.
The guidelines were developed by the pediatric antimicrobial stewardship program. Diagnosis and management of complicated intra abdominal infection in adults and children. In complicated intraabdominal infections, the infection progresses from a single organ and affects the peritoneum, causing intraabdominal abscesses or diffuse peritonitis. These updated guidelines replace those previously published in 2002 and 2003. These are guidelines only and not intended to replace clinical judgment. Less commonly, they can arise from the gynecologic or urinary tract. At the time the most recent guideline was released, the plan was to update the guideline every. In 2010, the surgical infection society and the infectious diseases society of america sisidsa created guidelines for the diagnosis and. The surgical infection society revised guidelines on the. Designing a classification which is accepted worldwide stratifying patients according to the their risk for poor prognosis may be important to modulate the treatment. However, in the setting of acute perforation, antifungal therapy is generally unnecessary unless the patient is immunosuppressed, has inflammatory bowel disease, has a perforation of a gastric ulcer on acid suppression or has postoperative or recurrent intra abdominal infection. Pdf antimicrobial management of intraabdominal infections. Abdominal sepsis represents the hosts systemic inflammatory response to intra abdominal infections. The inflammatory response in patients with sepsis depends on the causative pathogen and.
Complicated intraabdominal infection, which extends into the. Previous evidencebased guidelines on the management of intraabdominal infection iai were published by the surgical infection society sis in 1992, 2002, and 2010. According to the infectious diseases society of america idsa, complicated iai ciai is defined as an infection that extends beyond the wall of a. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary process. In complicated intraabdominal infections the infection extends beyond the hollow viscus of origin into the peritoneal space and is associated with either abscess formation or peritonitis, whereas an uncomplicated infection involves intramural inflammation of the gastrointestinal tract. Most patients should not complete their antimicrobial regimen orally after an uncomplicated secondary intraabdominal infection. Intraabdominal candidiasis european medical journal. In general, patients with a persistent or new intraabdominal infection, an organspace infection, or a superficial or deep surgicalsite infection can be identified through a careful physical examination.
Intraabdominal infections are the second most common cause of. However, in the setting of acute perforation, antifungal therapy is generally unnecessary unless the patient is immunosuppressed, has inflammatory bowel disease, has a perforation of a gastric ulcer on acid suppression or has postoperative or recurrent intraabdominal infection. Infection develops in 3050% of patients with necrosis documented by ct scan or at the time of surgery. Idsa releases guidelines on management of cryptococcal. Antibiotic management of complicated intraabdominal. The guidelines are intended for treating patients who either have these infections or may be at risk for them. Sepsis is a dynamic process that can evolve into conditions of varying severity 10, 11. Diagnosis, guide, intraabdominal infection, management. Recommendations for intraabdominal infections consensus report.
The asian consensus taskforce on complicated intraabdominal infections actciai met and discussed current clinical approaches to ciai management in asia, international guidelines on ciai management, microbiological trends of ciai pathogens in asia, and the existing antibiotic options. Most intraabdominal infections are secondary infections that are polymicrobial and are caused by a defect in the gastrointestinal gi tract that must be treated by surgical drainage, resection, andor repair. Evidencebased guidelines for managing patients with intraabdominal infection were prepared by an expert panel of the surgical infection society and the infectious diseases society of america. Surgical approach to peritonitis and abdominal sepsis. Updated guideline on diagnosis and treatment of intraabdominal. The idsa defines complicated and uncomplicated intraabdominal infections. Abdominal infections are usually polymicrobial and result in an intraabdominal abscess or secondary peritonitis, which may be generalized or localized phlegmon. Intraabdominal candidiasis iac is the second most common form of invasive candidiasis after candidaemia. Empiric coverage of yeast and enterococci is adults with communityassociated intraabdominal infection is not necessary. Intraabdominal infection iai, also spelled intraabdominal is a group of infections that occur within the abdominal cavity. Late and localized infections produces an intraabdominal abscess. Complicated intraabdominal infection subscriptions. Intraabdominal infections iais are common surgical emergencies and have been reported as major contributors to nontrauma deaths in the emergency departments worldwide.
This article may discuss investigational products or unapproved uses of products regulated by. Peak incidence of infection occurs in the 3rd week of disease. The surgical infections society sis and infectious diseases society of america idsa recommends that. Intraabdominal collection of pus or infected material, usually due to a localised infection inside the peritoneal cavity. Iac is a broad term and can be classified on the basis of anatomical site candida peritonitis, pancreatic candidiasis, biliary tract candidiasis, gastrointestinal candidiasis, and hepatosplenic candidiasis as well as clinical setting community acquired versus nosocomial. Society of america idsa and the surgical infection society sis to. Peritoneal contamination may result from surgeryassociated infection, trauma or spontaneous.
The approach to antimicrobial selection and administration for intraabdominal infections in adults is discussed. Prompt resuscitation of patients with ongoing sepsis is of utmost. The use of interval appendectomy after percutaneous drainage or nonoperative. Peritonitis and intraperitoneal abscesses infectious. Antibiotic duration for common infections emily spivak, md, mhs division of infectious diseases. Complicated intraabdominal infection is a common problem, with appendicitis alone affecting. Antimicrobial treatmdent of complicated intraabdominal. Intraabdominal candidiasis in patients who have had recent abdominal surgery or intraabdominal events refers to a heterogeneous group of infections that includes peritonitis, abdominal abscess, and purulent or necrotic infection at sites of gastrointestinal perforation or anastomotic leak. When the infection extends into the peritoneal cavity or another normally sterile region of the abdominal cavity, the infection is described as a complicated intraabdominal infection. Medical director, antimicrobial stewardship program. Original article from the new england journal of medicine trial of shortcourse antimicrobial therapy for intraabdominal infection. Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances.
Increased time to event with longer antibiotic therapy 10 vs 15 days infection with a resistant infection trended toward an increase with longer antibiotic therapy. Peritonitis is subdivided into primary, secondary, and tertiary varieties. For patients with septic shock, antibiotics should be administered as soon as possible aiii. Diagnosis and management of complicated intraabdominal infection in adults and children. Before sharing sensitive information, make sure youre on a federal government site. Recent guidelines from the infectious diseases society of america suggest that a compli cated intraabdominal infection is an intraabdominal infection coupled with any one of the following indi. Diagnosis and management of complicated intraabdominal. Four to seven days of antimicrobial treatment is typically adequate for intraabdominal infections with adequate source control. Idsa updates guidelines for management of intraabdominal. This article is intended for primary care physicians, surgeons, intensivists, and other specialists who care for hospitalized patients with intraabdominal infections.
Diagnosis and management of complicated intraabdominal infection in. Intraabdominal infection iai is a common disease pro cess managed by surgical. Idsa complicated intraabdominal infection guideline 1 2. Prophylactic antibiotics have been associated with a change in the spectrum of pancreatic isolates from enteric gramnegatives to grampositive organisms and fungi. The infectious diseases society of america and its hiv medicine association warned today that prematurely easing social distancing measures put in place to curtail the spread of covid19 will risk increased infections and deaths, incapacitated health care facilities, and prolonged economic hardships. Antimicrobial therapy should be initiated once a patient receives a diagnosis of an intraabdominal infection or once such an infection is considered likely. Early or diffuse infection results in localized or generalized peritonitis. Intraabdominal infection is the second most common cause of infectious mortality in the intensive care unit. Intraabdominal abscess guidelines bmj best practice. The infectious diseases society of america idsa represents physicians, scientists and other health care professionals who specialize in infectious diseases. Nonetheless, this disease classification encompasses a variety of processes that affect several different organs.
Most of the complicated intraabdominal infections treated by surgeons involve peritonitis or intraabdominal abscesses. Primary peritonitis is a monomicrobial infection in which the integrity of the gastrointestinal tract has not been violated. Psapvii infectious diseases 181 intraabdominal infections agreed on clinically. Antimicrobial approach to intraabdominal infections in adults. It can involve any intraabdominal organ or be located in between bowel loops, or be free within the peritoneal cavity itself. Updated recommendations for nonoperative management of acute appendicitis are among the key changes to the guidelines for the diagnosis and management of complicated intraabdominal infection in. At the time the most recent guideline was released, the plan was to update the guideline every five years to ensure the timeliness and appropriateness of the recommendations.
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